WHAT IS A CBG ?
CBG (cannabigerol) is one of more than a hundred phytocannabinoids found in hemp. The compounds called cannabinoids, together with the basic terpenes and flavonoids, make up the chemical structure of hemp. CBG can help balance the effects of THC and other cannabinoids by supporting the synergy between the compounds. An 'activated' version of CBG, (CBGA) is also a precursor (a compound involved in a reaction to produce another compound) to CBD, THC, CBN, CBC and dozens of other cannabinoids. CBGA is considered a strain molecule and without it, the vast world of influential cannabinoids would not exist. CBGA exists only in raw hemp plants after extraction and decarboxylation.
CBG accounts for less than 1% of the total cannabinoid content in a full spectrum formula. Therefore, one way of producing CBG-rich extract is at a much earlier stage of the plant harvest cycle. In this case, THC and CBD are sacrificed in order to maximise the amount of CBG produced. Another way to increase CBG yield is to cross varieties and optimise them.
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Cannabigerol (CBG) is a non-psychoactive cannabinoid that is gaining attention for its antibacterial, antimicrobial analgesic and anti-inflammatory properties. Its positive effects are similar to the more common CBD, but there are some areas where CBG oil is proving more effective.
CBG acts on the central nervous system, so the research available so far suggests that it may show promise in relieving various neurological disorders, skin conditions and chronic pain. Both CBD and CBG have been observed to have synergistic effects, i.e. they increase the therapeutic effect when used together.
CBG has also been shown to increase the production of anandamide, commonly referred to as the "happy molecule", an endogenous cannabinoid that helps regulate a number of body functions, including appetite, sleep, mood and the immune system.
The interaction between cannabinoids and the endocannabinoid system usually occurs through direct activation of CB₁ and CB₂ receptors. These receptors act as entry points for cannabinoids, allowing them to elicit a wide range of biological responses. It is thought that CBG behaves in the same way, partially activating CB₂ receptors but showing a stronger affinity for CB₁ receptors. While the exact mechanism of action is still being investigated, scientists have been able to confirm that CBG is an effective regulator of endocannabinoid signalling and that it may have therapeutic effects.
Possible therapeutic effects:
Stimulates bone formation and healing. A 2007 study investigated the effects of CBG and other cannabinoids on bone marrow cultures. The results showed that CBG can stimulate bone marrow stem cells via the CB2 receptor. This suggests that CBG and other cannabinoids may help heal bone fractures by promoting new bone formation.
It slows the growth of tumours. A study published in 1996 found that CBG had an anti-cancer effect on melanoma. The study found that CBG significantly reduced the growth of melanoma cells in the skin of mice. Another study by the same authors, conducted in 1998, compared the anti-cancer effects of CBG with several other substances, including geraniol, olivetol, etc. The study found that CBG had the highest growth-inhibitory effect against cancer cells of all the substances tested.
In conclusion, CBG shows promising in vitro properties for the potential treatment of a wide range of cancers, including breast, liver, lung, pancreatic, skin, ovarian, kidney, bladder and colon cancer.
Antifungal and antibacterial activity. The antifungal and antibacterial properties of various cannabinoids, including CBG, are currently under investigation. A 2008 study showed that CBG was effective against MRSA. MRSA (Methicillin-resistant Staphylococcus aureus) is a very common strain of antibiotic-resistant bacteria.
It relieves pain. The analgesic effects of CBG and other cannabinoids are well known in various diseases, including multiple sclerosis and cancer pain. According to an article published in 2008, clinical trials have shown that synthetic cannabinoids are well tolerated and effective, and can be used in combination with other drugs to relieve pain.
A 2011 patent from Otsuka Pharmaceutical and GW Pharma claims that cannabigerol and other cannabinoids (such as CBC, CBDV and THCV) can help relieve the symptoms of neuropathic pain in mice. Research by the two pharmaceutical giants shows that CBG helped mice recover from pain caused by surgically induced nerve damage.
It reduces inflammation. Cannabinoids such as CBG have the ability to reduce inflammation by targeting the molecules responsible for the development of inflammation in a variety of diseases, including pain syndromes, cancer and inflammatory bowel disease. Studies show that CBG can act as a COX-2 inhibitor, similar to non-steroidal anti-inflammatory drugs (NSAIDs). A patent application by GW Pharmaceuticals suggests that CBG, along with other cannabinoids, may be effective in the treatment of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease.
Treating overactive bladder function. Cannabis and cannabinoid preparations have been used to treat various bladder dysfunctions. In a 2015 study, researchers tested the effects of CBG and other cannabinoids on artificially induced bladder contractions. They found that CBG and THCV had the strongest effect on reducing bladder contractions.
Psoriasis and dermatology. CBG and other cannabinoids may be useful in the treatment of various skin conditions due to the presence of cannabinoid receptors in the skin. In a 2007 study, CBG was shown to inhibit keratinocyte proliferation, which raises the role of CBG in the treatment of psoriasis.
Depression and anxiety management. It is known that THC can help patients suffering from depression and anxiety. CBG has been found to have a similar effect, but without the known stupor of THC. A 2016 report suggests that non-psychotropic cannabinoids such as CBG may be suitable alternatives for the treatment of anxiety and depression.
According to GW's patent application, CBG has antidepressant effects similar to those of imipramine, a drug used to treat major depression.
"Inflammation and oxidative stress play an important role in neurodegeneration," the researchers write. "Interestingly, various natural compounds may have neuroprotective effects against inflammation and oxidative stress, protecting against neuronal cell loss. Among these natural sources, Cannabis sativa is a reservoir of compounds that express beneficial properties, including cannabigerol (CBG), whose antioxidant properties have already been shown in macrophages."
Macrophages can be either large phagocytic cells in tissues in a stationary state or motile white blood cells, usually found at the site of infection.
The researchers conclude, "...the results showed that the neuroprotective effects of CBG are a potential treatment against neuroinflammation and oxidative stress."
It is important to note that the majority of the evidence is based on preclinical studies, and therefore the safety and efficacy of CBG has not been proven in human subjects. We still do not fully understand how CBG interacts with the endocannabinoid system. Nevertheless, studies on CBG point to a number of potential benefits of the substance. Before you start taking CBG, consult your doctor for advice that is right for you.
The information on this site is not in itself suitable for you to make your own diagnosis! The product is not recommended for pregnant or breastfeeding women. If you are taking prescription medication or have a serious medical condition, always consult your doctor or the appropriate specialist before using these products. CBG, oils and supplements are not a substitute for medication, a balanced mixed diet and a healthy lifestyle. There is no information on this site that claims that our products cure or treat any disease. Keep out of reach of children!
All hemp products presented on this website are 100% legal under EU legislation. Produced from hemp strains from an EU certified variety catalogue with a THC content of less than 0.2% in accordance with legislation. None of our products are psychoactive.
Storage of CBG oil: store in a cool, dry place away from light to preserve the ingredients.